Office: MH-582E
Phone: (657) 278-2471
Email: specic@fullerton.edu
Lab: DBH-179
Phone: (657) 278-5295
Stevan Pecic
Assistant Professor Medicinal and Bioorganic ChemistryResearch Interests
Development of novel inhibitors of enzymes involved in lipid metabolism and their evaluation as potential therapeutics using traditional medicinal chemistry techniques (in silico drug design, synthesis, structure-activity relationship (SAR) studies and in vitro biological assays). We are also focused on the identification of DNA-aptameric sensors for small molecules in so-called structure-switching format using SELEX procedure. We are in particular interested in aptamers for small molecules such as steroids and drugs that regulate pain and inflammation. Aptamers generated via SELEX hold promise for bioimaging, drug development, drug discovery, disease diagnosis, hazard detection, food inspection and many other biomedical applications.
Education
Postdoctoral- Columbia University Medical Center, New York
Ph.D. The City University of New York, Graduate School and University Center
M.Phil. The City University of New York, Graduate School and University Center
Dipl.Pharm. Faculty of Pharmacy, University of Belgrade, Serbia
Selected Publications
For a full list of publications please visit the Pecic Lab Website
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Alizadeh, J; da Silva Rosa, SC; Weng, X; Jacobs, J; Lorzadeh, S; Ravandi, A; Vitorino, R; Pecic, S; Zivkovic, A; Stark, H; Shojaei, S; Ghavami, S. Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy.
European Journal of Cell Biology (2023),151337.
Stec, J; Xie, S; Alshukri, L; Kang, GJ; Hudson, PK; Pecic, S. Convenient synthesis and in vitro activity of oxalyl bis(benzenesulfonylhydrazides) and related compounds
. Results in Chemistry (2023), 5, 100860.
Angelia, J; Weng, X; Solomatov, A; Chin, C; Fernandez, A; Hudson, PK; Morisseau, C; Hammock, BD; Kandasamy, R; Pecic, S. Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior
. Prostaglandins & Other Lipid Mediators (2023), 164, 106702.
Naeimi, R; Najafi, R; Molaei, P; Amini, R; Pecic, S. Nanoparticles: The future of effective diagnosis and treatment of colorectal cancer?
European Journal of Pharmacology (2022), 175350.
Eshraghi, M.; Ahmadi, M.; Afshar, S.; Lorzadeh, S.; Adlimoghaddam, A.; RezvaniJalal, N.; West, R.; Dastghaib, S.; Igder, S.; Torshizi, S.R.N.; Mahmoudzadeh. A.; Mokarram, P.; Madrakian, T.; Albensi, B. C.; Los, M.J.; Ghavami, S.; Pecic, S. Enhancing Autophagy in Alzheimer's Disease Through Drug Repositioning. Pharmacology & Therapeutics (2022), 108171.
Stec, J; Pecic, S. Facile synthesis of the fungus-derived natural products: N,N′-dipalmitoleyl urea (C16:1) and N,N′-dioleyl urea (C18:1)
, Natural Product Research (2022), 36 (8), 2158-2165.
Makarian, M.; Gonzalez, M.; Salvador, SM.; Lorzadeh, S.; Hudson, P.K.; Pecic, S. Synthesis, Kinetic Evaluation and Molecular Docking Studies of Donepezil-Based Acetylcholinesterase Inhibitors. Journal of Molecular Structure (2022), 1247, 131425.
Wilt, S.; Kodani, S.; Valencia, L.; Hudson, P. K.; Sanchez, S.; Quintana, T.; Morisseau, C.; Hammock, B. D.; Kandasamy, R.; Pecic, S. Further Exploration of the Structure-Activity Relationship of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. Bioorganic & Medicinal Chemistry (2021), 51, 116507.
Courses Taught
Spring 2024 Office Hours
Wed 3pm-4pm.
